General Information
-
DRAMP ID
- DRAMP03631
-
Peptide Name
- Beta-defensin 136 (Defensin, beta 136; Human, mammals, animals)
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Source
- Homo sapiens (Human)
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Family
- Belongs to the beta-defensin family
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Gene
- DEFB136
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Sequence
- MFGNDGVKVRTCTSQKAVCFFGCPPGYRWIAFCHNILSCCKNMTRFQPPQAKDPWVH
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Sequence Length
- 57
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03631.
Physicochemical Information
-
Formula
- C291H436N82O74S8
Absent Amino Acids
- E
Common Amino Acids
- CFP
Mass
- 6523.65
PI
- 9.12
Basic Residues
- 9
Acidic Residues
- 2
Hydrophobic Residues
- 17
Net Charge
- +7
-
Boman Index
- -72.86
Hydrophobicity
- -0.212
Aliphatic Index
- 46.14
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 12865
Absorbance 280nm
- 229.73
Polar Residues
- 19
DRAMP03631
Comments Information
Function
- Has antibacterial activity (Potential).
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
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Pubmed ID
- 16033865
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Reference
- Physiol Genomics. 2005 Sep 21;23(1):5-17.
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Author
- Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.