General Information

    • DRAMP ID

    • DRAMP03640

    • Peptide Name

    • Hcl-hst 5 (N.leucogenys histatin 5)

    • Source

    • Nomascus leucogenys

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DSHEKRHHEHRRKFHEKHHSHRGY

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix (CD)

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03640 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03640.

Physicochemical Information

    • Formula

    • C135H199N55O36

    • Absent Amino Acids

    • ACILMNPQTVW

    • Common Amino Acids

    • H

    • Mass

    • 3168.41

    • PI

    • 9.99

    • Basic Residues

    • 15

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 1

    • Net Charge

    • +11

    • Boman Index

    • -145.78

    • Hydrophobicity

    • -2.908

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 64.78

    • Polar Residues

    • 4

DRAMP03640

DRAMP03640 chydropathy plot

Comments Information

    • Rich in histidines. Partial helical in 50% TFE.

Literature Information

  • ·Literature 1

    • Title

    • Histatins In Non-Human Primates: Gene Variations and Functional Effects.

    • Reference

    • Protein Pept Lett. 2010 Jul;17(7):909-918.

    • Author

    • Padovan L, Segat L, Pontillo A, Antcheva N, Tossi A, Crovella S.