General Information

    • DRAMP ID

    • DRAMP03642

    • Peptide Name

    • Chicken heterophil peptides 1 (Antimicrobial peptide CHP1; Birds, animals)

    • Source

    • Gallus gallus (Chicken)

    • Family

    • Belongs to the beta-defensin family

    • Gene

    • Not found

    • Sequence

    • GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIR

    • Sequence Length

    • 39

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.7 µg/ml);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=0.7 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys6 and Cys28,Cys13 and Cys34,Cys18 and Cys35.

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03642 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C196H321N59O49S6

    • Absent Amino Acids

    • EHMNQVW

    • Common Amino Acids

    • C

    • Mass

    • 4480.43

    • PI

    • 9.9

    • Basic Residues

    • 10

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +9

    • Boman Index

    • -77.03

    • Hydrophobicity

    • -0.054

    • Aliphatic Index

    • 62.56

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 49.08

    • Polar Residues

    • 16

DRAMP03642

DRAMP03642 chydropathy plot

Comments Information

    • Function

    • Bactericidal activity; inhibits S. aureus and E. coli.

    • PTM

    • Contains three disulfide bonds 6-28; 13-34; 18-35.

Literature Information

  • ·Literature 1

    • Title

    • Isolation of antimicrobial peptides from avian heterophils.

    • Reference

    • J Leukoc Biol. 1994 Nov;56(5):661-665.

    • Author

    • Evans EW, Beach GG, Wunderlich J, Harmon BG.