General Information

    • DRAMP ID

    • DRAMP03687

    • Peptide Name

    • TsAP-1 (T. serrulatus antimicrobial peptide 1; scorpions, arachnids, invertebrates, animals)

    • Source

    • Tityus serrulatus (Brazilian yellow scorpion)

    • Family

    • Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.

    • Gene

    • Not found

    • Sequence

    • FLSLIPSLVGGSISAFK

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer

    • Target Organism

      • [Ref.23770440] Gram-positive bacteria : Staphylococcus aureus(MIC=120 μM, MBC>160 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=160 μM, MBC>160 μM);
      • Fungi : Candida albicans(MIC=160 μM, MBC>160 μM)

    • Hemolytic Activity

      • [Ref.23770440] 0% hemolysis at 40 μM , 2% hemolysis at 80 μM , 5% hemolysis at 120 μM , 7% hemolysis at 160 μM against horse red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03687 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C83H134N18O22

    • Absent Amino Acids

    • CDEHMNQRTWY

    • Common Amino Acids

    • S

    • Mass

    • 1736.08

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • 19.14

    • Hydrophobicity

    • 1.324

    • Aliphatic Index

    • 137.65

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP03687

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Anticancer activity against HI57 and H838.

Literature Information

  • ·Literature 1

    • Title

    • Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities.

    • Reference

    • Biochimie. 2013 Jun 14. doi: 10.1016/j.biochi.2013.06.003.

    • Author

    • Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C.