General Information
-
DRAMP ID
- DRAMP03688
-
Peptide Name
- TsAP-2 (T. serrulatus antimicrobial peptide 2; scorpions, arachnids, invertebrates, animals)
-
Source
- Tityus serrulatus (Brazilian yellow scorpion)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- FLGMIPGLIGGLISAFK
-
Sequence Length
- 17
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Anti-cancer
-
Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus (MIC=5 µM).
- Yeast: Candida albicans (MIC=10 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03688.
Physicochemical Information
-
Formula
- C84H136N18O19S
Absent Amino Acids
- CDEHNQRTVWY
Common Amino Acids
- G
Mass
- 1734.17
PI
- 8.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +1
-
Boman Index
- 34.45
Hydrophobicity
- 1.547
Aliphatic Index
- 143.53
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP03688
Comments Information
Function
- TsAP-2 was of high potency against the Gram-positive bacterium, Staphylococcus aureus and the yeast Candida albicans.
Literature Information
- ·Literature 1
-
Title
- Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities.
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Pubmed ID
- 23770440
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Reference
- Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8.
-
Author
- Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C.