General Information

    • DRAMP ID

    • DRAMP03688

    • Peptide Name

    • TsAP-2 (T. serrulatus antimicrobial peptide 2; scorpions, arachnids, invertebrates, animals)

    • Source

    • Tityus serrulatus (Brazilian yellow scorpion)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLGMIPGLIGGLISAFK

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Anti-cancer

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=5 µM).
      • Yeast: Candida albicans (MIC=10 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03688 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03688.

Physicochemical Information

    • Formula

    • C84H136N18O19S

    • Absent Amino Acids

    • CDEHNQRTVWY

    • Common Amino Acids

    • G

    • Mass

    • 1734.17

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • 34.45

    • Hydrophobicity

    • 1.547

    • Aliphatic Index

    • 143.53

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP03688

Comments Information

    • Function

    • TsAP-2 was of high potency against the Gram-positive bacterium, Staphylococcus aureus and the yeast Candida albicans.

Literature Information

  • ·Literature 1

    • Title

    • Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities.

    • Reference

    • Biochimie. 2013 Jun 14. pii: S0300-9084(13)00164-8.

    • Author

    • Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C.