General Information

    • DRAMP ID

    • DRAMP03700

    • Peptide Name

    • Antimicrobial peptide ctriporin (Riporin; Arthropods, animals)

    • Source

    • Chaerilus tricostatus (Scorpion)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLWGLIPGAISAVTSLIKK

    • Sequence Length

    • 19

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=5 µg/ml), Micrococcus luteus (MIC=5 µg/ml), Bacillus thuringiensis (MIC=10 µg/ml), B. subtilis (MIC=10 µg/ml).
      • Fungi: Candida albicans (MIC=20 µg/ml).
      • Antibiotic-resistant pathogens: methicillin-resistant Staphylococcus aureus (MIC=5-10 µg/ml), penicillin-resistant S. epidermidis (MIC=10 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03700 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03700.

Physicochemical Information

    • Formula

    • C98H160N22O23

    • Absent Amino Acids

    • CDEHMNQRY

    • Common Amino Acids

    • IL

    • Mass

    • 2014.48

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 23.9

    • Hydrophobicity

    • 1.163

    • Aliphatic Index

    • 148.95

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 305.56

    • Polar Residues

    • 5

DRAMP03700

DRAMP03700 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide that acts by breaking the cell wall. Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Is efficient in curing staphylococcal skin infection in mice, when externally applied.

    • Tissue specificity

    • Expressed by the venom gland.

    • Miscellaneous

    • Has no activity against Gram-negative bacteria (E.coli and P.aeruginosa).

Literature Information

  • ·Literature 1

    • Title

    • Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus.

    • Reference

    • Antimicrob Agents Chemother. 2011 Nov;55(11):5220-9.

    • Author

    • Fan Z, Cao L, He Y, Hu J, Di Z, Wu Y, Li W, Cao Z.