General Information

    • DRAMP ID

    • DRAMP03706

    • Peptide Name

    • Antimicrobial peptide 1 (AamAP1; Arthropods, animals)

    • Source

    • Androctonus amoreuxi (African fattail scorpion)

    • Family

    • Not found

    • Gene

    • ap1

    • Sequence

    • FLFSLIPHAIGGLISAFK

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=20 µM);
      • Gram-negative bacterium: Escherichia coli (MIC=150 µM).
      • Yeast: Candida albicans (MIC=64 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03706 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C96H147N21O21

    • Absent Amino Acids

    • CDEMNQRTVWY

    • Common Amino Acids

    • FIL

    • Mass

    • 1931.35

    • PI

    • 8.76

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 26.95

    • Hydrophobicity

    • 1.433

    • Aliphatic Index

    • 141.11

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP03706

DRAMP03706 chydropathy plot

Comments Information

    • Function

    • Has antibacterial and antifungal activity. Causes hemolysis on horse erythrocytes.

    • Tissue specificity

    • Expressed by the venom gland.

    • PTM

    • C-termianal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog.

    • Reference

    • Peptides. 2012 Jun;35(2):291-299.

    • Author

    • Almaaytah A, Zhou M, Wang L, Chen T, Walker B, Shaw C.