General Information

    • DRAMP ID

    • DRAMP03708

    • Peptide Name

    • Tddefensin (Arthropods, animals)

    • Source

    • Tityus discrepans (Venezuelan scorpion)

    • Family

    • Belongs to the invertebrate defensin family

    • Gene

    • Not found

    • Sequence

    • RYCPRNPEACYNYCLRTGRPGGYCGGRSRITCFCFR

    • Sequence Length

    • 36

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03708 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03708.

Physicochemical Information

    • Formula

    • C178H271N59O48S6

    • Absent Amino Acids

    • DHKMQVW

    • Common Amino Acids

    • R

    • Mass

    • 4197.84

    • PI

    • 9.38

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +6

    • Boman Index

    • -103.64

    • Hydrophobicity

    • -0.708

    • Aliphatic Index

    • 24.44

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 6335

    • Absorbance 280nm

    • 181

    • Polar Residues

    • 20

DRAMP03708

DRAMP03708 chydropathy plot

Comments Information

    • Function

    • Antibacterial peptide mostly active against Gram-positive bacteria (By similarity).

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans.

    • Reference

    • Biochimie. 2009 Aug;91(8):1010-1019.

    • Author

    • D'Suze G, Schwartz EF, García-Gómez BI, Sevcik C, Possani LD.