General Information

    • DRAMP ID

    • DRAMP03712

    • Peptide Name

    • Peptide Hp1090 (Non-disulfide-bridged peptide 5.9, NDBP-5.9; Arthropods, animals)

    • Source

    • Heterometrus petersii (Asian forest scorpion)

    • Family

    • Belongs to the scorpion NDBP 5 family

    • Gene

    • Not found

    • Sequence

    • IFKAIWSGIKSLF

    • Sequence Length

    • 13

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antiviral

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Binding to HCV

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix (CD)

    • Structure Description

    • CD spectroscopy analysis indicates that Hp1090 is an amphipathic α-helical peptide that prevents the initiation of HCV infection by directly interactingwith viral particles and rapidly permeabilizing their phospholipid membranes.

    • Helical Wheel Diagram

    • DRAMP03712 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03712.

Physicochemical Information

    • Formula

    • C76H116N16O16

    • Absent Amino Acids

    • CDEHMNPQRTVY

    • Common Amino Acids

    • I

    • Mass

    • 1509.85

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • 12.82

    • Hydrophobicity

    • 1.077

    • Aliphatic Index

    • 127.69

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 458.33

    • Polar Residues

    • 3

DRAMP03712

Comments Information

    • Function

    • The peptide showed antibacterial activity against both Gram-negative and Gram-positive bacteria.

    • Tissue specificity

    • Expressed by the venom gland.

    • Miscellaneous

    • This peptide has a significant inhibitory effect on hepatitis C virus (HCV) infection (IC50=7.62 µg/ml). Furthermore, this peptide potently inhibits HCV before viral entry into cells and kills HCV rapidly in vitro.

    • PTM

    • C-terminal amidation (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • A new natural alpha-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV.

    • Reference

    • Peptides. 2011 Jan;32(1):11-19.

    • Author

    • Yan R, Zhao Z, He Y, Wu L, Cai D, Hong W, Wu Y, Cao Z, Zheng C, Li W.