General Information
-
DRAMP ID
- DRAMP03713
-
Peptide Name
- Peptide Hp1035 (Non-disulfide-bridged peptide 5.10, NDBP-5.10; Arthropods, animals)
-
Source
- Heterometrus petersii (Asian forest scorpion)
-
Family
- Belongs to the scorpion NDBP 5 family
-
Gene
- Not found
-
Sequence
- IFSAIGGFLKSIF
-
Sequence Length
- 13
-
UniProt Entry
- P0DJ03
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03713.
Physicochemical Information
-
Formula
- C70H106N14O16
Absent Amino Acids
- CDEHMNPQRTVWY
Common Amino Acids
- FI
Mass
- 1399.7
PI
- 8.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- 19.96
Hydrophobicity
- 1.631
Aliphatic Index
- 127.69
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP03713
Comments Information
Function
- Amphipathic peptide with probable antibacterial activities. Hp1035 peptide, showing high homology to Hp1090, exhibited no anti-HCV activity.
Tissue specificity
- Expressed by the venom gland.
PTM
- C-terminal amidation (By similarity).
Literature Information
- ·Literature 1
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Title
- A new natural alpha-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV.
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Pubmed ID
- 20950663
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Reference
- Peptides. 2011 Jan;32(1):11-19.
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Author
- Yan R, Zhao Z, He Y, Wu L, Cai D, Hong W, Wu Y, Cao Z, Zheng C, Li W.