General Information

    • DRAMP ID

    • DRAMP03714

    • Peptide Name

    • VmCT1

    • Source

    • Vaejovis mexicanus smithi (Scorpion)

    • Family

    • Belongs to the scorpion NDBP 5 family

    • Gene

    • Not found

    • Sequence

    • FLGALWNVAKSVF

    • Sequence Length

    • 13

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.27912176] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=3.12 μmol/L), Bacillus subtilis ATCC 6633 (MIC=25μmol/L), Staphylococcus epidermidis ATCC 12228 (MIC=3.12μmol/L);
      • Gram-negative bacterium: Pseudomonas aeruginosa ATCC 27853 (MIC=0.78μmol/L), Escherichia coli D31 (MIC=3.12μmol/L), Serratia marcescens ATCC 4112 (MIC=1.56μmol/L), Enterobacter cloacae β-12 (MIC=25μmol/L), Micrococcus luteus A270 (MIC=1.56μmol/L);
      • Fungi: Candida albicans MDM8 (MIC=12.5μmol/L), Candida tropicalis IOC 4560 (MIC=6.25μmol/L), Candida parapsilosis IOC 4564 (MIC=25μmol/L), Aspergillus niger (MIC=25μmol/L), Cladosporium herbarum ATCC 26362 (MIC=50μmol/L), Cryptococcus neoformans (MIC=3.12μmol/L)

    • Hemolytic Activity

      • [Ref.27912176] 10% hemolysis at 1.99μmol/L against human red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix, random coil

    • Structure Description

    • the peptide showed a coiled structure in water, zwitterionic lipid vesicles (POPC and POPC:DOPE) and negatively charge lipid vesicle (POPC:POPG) the analogs tend to adopt helical structures.

    • Helical Wheel Diagram

    • DRAMP03714 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03714.

Physicochemical Information

    • Formula

    • C72H106N16O16

    • Absent Amino Acids

    • CDEHIMPQRTY

    • Common Amino Acids

    • AFLV

    • Mass

    • 1451.73

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • 15.18

    • Hydrophobicity

    • 1.208

    • Aliphatic Index

    • 120

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 458.33

    • Polar Residues

    • 3

DRAMP03714

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria, antifungal activity. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Novel designed VmCT1 analogs with increased antimicrobial activity

    • Reference

    • Eur J Med Chem. 2017 Jan 27;126:456-463.

    • Author

    • Pedron CN, Torres MT, Lima JADS, Silva PI, Silva FD, Oliveira VX.