General Information

    • DRAMP ID

    • DRAMP03717

    • Peptide Name

    • Meucin-24 (Arthropods, animals)

    • Source

    • Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)

    • Family

    • Long chain scorpion toxin family (Class 2 subfamily)

    • Gene

    • Not found

    • Sequence

    • GRGREFMSNLKEKLSGVKEKMKNS

    • Sequence Length

    • 24

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimalarial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.20097251]Non-hemolytic effect against mouse erythrocytes even at 100 μM

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix (1 helices; 17 residues)

    • Structure Description

    • Circular dichroism (CD) analysis of chemically synthesized peptides demonstrates that meucin-24 presents an essential random coil conformation in water, but its alpha-helical content largely increases in the presence of 50% trifluoroethanol, a membrane-mimicking environment.

    • Helical Wheel Diagram

    • DRAMP03717 helical wheel diagram

    • PDB ID

    • 2KFE resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP03717.

Physicochemical Information

    • Formula

    • C116H201N37O36S2

    • Absent Amino Acids

    • ACDHIPQTWY

    • Common Amino Acids

    • K

    • Mass

    • 2754.22

    • PI

    • 10.17

    • Basic Residues

    • 7

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +4

    • Boman Index

    • -77.12

    • Hydrophobicity

    • -1.3

    • Aliphatic Index

    • 44.58

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP03717

DRAMP03717 chydropathy plot

Comments Information

    • Function

    • The synthetic meucin-24 inhibits the development of P. berghei ookinetes, kills intraerythrocytic P.falciparum, and is cytotoxic to the Drosophila S2 cell at micromolar concentrations. No hemolytic activities have been found at micromolar concentrations.

    • Tissue specificity

    • Expressed by the venom gland.

    • Miscellaneous

    • The RNA coding for this protein is silently edited.

    • PTM

    • Contains three disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Characterization of two linear cationic antimalarial peptides in the scorpion Mesobuthus eupeus.

    • Reference

    • Biochimie. 2010 Apr;92(4):350-359.

    • Author

    • Gao B, Xu J, Rodriguez Mdel C, Lanz-Mendoza H, Hernández-Rivas R, Du W, Zhu S.