• • DRAMP ID

  • DRAMP03718

• • Peptide Name

  • Meucin-25 (BeL-170; Arthropods, animals)

• • Source

  • Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • VKLIQIRIWIQYVTVLQMFSMKTKQ

• • Sequence Length

  • 25

• • UniProt Entry

  • P0CH58

• • Protein Existence

  • Transcript level

• • Biological Activity

  • Antimalarial

• • Target Organism

  • No MICs found in DRAMP database

• • Hemolytic Activity

  • • [Ref.20097251]Non-hemolytic effect against mouse erythrocytes even at 101 μM

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • CD results indicate that meucin-25 mainly adopts a beta-sheet structure in water but TFE promotes its alpha-helical formation, suggesting its conformational flexibility.

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP03718.

DRAMP03718

• • Function

  • This synthetic cationic peptide inhibits the development of Plasmodium berghei ookinetes, kills intraerythrocytic P. falciparum, and is cytotoxic to the Drosophila S2 cell at micromolar concentrations. No hemolytic activities have been found at micromolar concentrations.

• • Tissue specificity

  • Expressed by the venom gland.

• ·Literature 1

• • Title

  • Characterization of two linear cationic antimalarial peptides in the scorpion Mesobuthus eupeus.

• • Pubmed ID

  • 20097251

• • Reference

  • Biochimie. 2010 Apr;92(4):350-359.

• • Author

  • Gao B, Xu J, Rodriguez Mdel C, Lanz-Mendoza H, Hernández-Rivas R, Du W, Zhu S.