General Information
-
DRAMP ID
- DRAMP03720
-
Peptide Name
- 4 kDa defensin (Antibacterial 4 kDa peptide; Arthropods, animals)
-
Source
- Leiurus quinquestriatus hebraeus (Yellow scorpion)
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Family
- Belongs to the invertebrate defensin family (Type 2 subfamily)
-
Gene
- Not found
-
Sequence
- GFGCPLNQGACHRHCRSIRRRGGYCAGFFKQTCTCYRN
-
Sequence Length
- 38
-
UniProt Entry
- P41965
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03720.
Physicochemical Information
-
Formula
- C181H279N65O48S6
Absent Amino Acids
- DEMVW
Common Amino Acids
- CGR
Mass
- 4325.97
PI
- 9.69
Basic Residues
- 9
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +9
-
Boman Index
- -101.85
Hydrophobicity
- -0.653
Aliphatic Index
- 25.79
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 90.68
Polar Residues
- 19
DRAMP03720
Comments Information
Function
- Antibacterial protein against Gram-positive bacteria; may act via membrane-permeabilization of these cells.
PTM
- Contains three disulfide bonds 4-25; 11-33; 15-35 (By similarity).
Literature Information
- ·Literature 1
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Title
- Purification and characterization of a scorpion defensin, a 4kDa antibacterial peptide presenting structural similarities with insect defensins and scorpion toxins.
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Pubmed ID
- 8333834
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Reference
- Biochem Biophys Res Commun. 1993 Jul 15;194(1):17-22.
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Author
- Cociancich S, Goyffon M, Bontems F, Bulet P, Bouet F, Menez A, Hoffmann J.