General Information

    • DRAMP ID

    • DRAMP03721

    • Peptide Name

    • IsCT1

    • Source

    • Opisthacanthus madagascariensis

    • Family

    • Belongs to the scorpion NDBP 5 family

    • Gene

    • Not found

    • Sequence

    • ILGKIWEGIKSLF

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.28657596] Gram-positive bacterium:Staphylococcus aureus (MIC=50μg/mL);
      • Gram-negative bacterium: S. typhimurium (MIC=100μg/mL), Escherichia coli (MIC=50μg/mL)

    • Hemolytic Activity

      • [Ref.28657596] 2% hemolysis at 10 μg/ml, 96% hemolysis at 50 μg/ml against human red blood cells.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Residue 6 is important for antibacterial activity, and hemolysis activity

    • Helical Wheel Diagram

    • DRAMP03721 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03721.

Physicochemical Information

    • Formula

    • C74H118N16O17

    • Absent Amino Acids

    • ACDHMNPQRTVY

    • Common Amino Acids

    • I

    • Mass

    • 1503.85

    • PI

    • 8.59

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 10.48

    • Hydrophobicity

    • 0.777

    • Aliphatic Index

    • 150

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 458.33

    • Polar Residues

    • 3

DRAMP03721

Comments Information

    • Function

    • Antibacterial activity against the Gram-negative bacteria and Gram-positive bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides

    • Reference

    • Antibiotics (Basel). 2017 Jun 28;6(3). pii: E13.

    • Author

    • de la Salud Bea R, Petraglia AF, Ascuitto MR, Buck QM.