General Information
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DRAMP ID
- DRAMP03737
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Peptide Name
- Opistoporin-4 (Non-disulfide-bridged peptides 3.7, NDBP-3.7; Arthropods, animals)
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Source
- Opistophthalmus carinatus (African yellow leg scorpion)
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Family
- Belongs to the antimicrobial peptide scorpion family
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Gene
- Not found
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Sequence
- GKVWDWIKKTAKDVLNSDVAKQLKNKALNAAKNFVAEKIGATPS
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Sequence Length
- 44
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UniProt Entry
- Q5VJS9
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Protein Existence
- Transcript level
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
- [Swiss_Prot Entry Q5VJS9]strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity.
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Hemolytic Activity
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- [Swiss_Prot Entry Q5VJS9]Weak hemolytic activity against human erythrocytes
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Cytotoxicity
-
- Not included yet
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Binding Target
- Cell membrane
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
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PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03737.
Physicochemical Information
-
Formula
- C217H356N60O62
Absent Amino Acids
- CHMRY
Common Amino Acids
- K
Mass
- 4797.58
PI
- 9.9
Basic Residues
- 9
Acidic Residues
- 4
Hydrophobic Residues
- 19
Net Charge
- +5
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Boman Index
- -64.01
Hydrophobicity
- -0.482
Aliphatic Index
- 86.59
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 255.81
Polar Residues
- 10
DRAMP03737
Comments Information
Function
- At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells. At submicromolar concentrations, degranulates granulocytes and has weak hemolytic activity against human red blood cells. Also strongly inhibits the production of superoxide anions. Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria. Also has antifungal activity. (By similarity)
Tissue specificity
- Expressed by the venom gland.
Literature Information
- ·Literature 1
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Title
- Precursor organization and gene structure of scorpion venom antimicrobial peptides.
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Pubmed ID
- PubMed ID is not available
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Reference
- Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
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Author
- Zhu S, Tytgat J.