• DRAMP ID

    • DRAMP03746
    • Peptide Name

    • Peptide BmKn2 (Biologically active peptide 4; NDBP-5.1; Arthropods, animals)
    • Source

    • Mesobuthus martensii (Buthus martensii)
    • Family

    • Not found
    • Gene

    • Kn2
    • Sequence

    • FIGAIARLLSKIF
    • Sequence Length

    • 13
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=0.6 µg/ml), Micrococcus luteus(MIC=8 µg/ml), Bacillus subtilis (MIC=5 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=1.5 µg/ml), Pseudomonas aeruginosa (MIC=21.3 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03746 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C71H117N17O15
    • Absent Amino Acids

    • CDEHMNPQTVWY
    • Common Amino Acids

    • I
    • Mass

    • 1448.81
    • PI

    • 11
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +2
    • Boman Index

    • 11.25
    • Hydrophobicity

    • 1.592
    • Aliphatic Index

    • 165.38
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP03746

    • Function

    • Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.
    • Tissue specificity

    • Expressed by the venom gland.
    • PTM

    • C-terminal amidation.
  • ·Literature 1
    • Title

    • Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch.
    • Reference

    • Peptides. 2004 Feb;25(2):143-150.
    • Author

    • Zeng XC, Wang SX, Zhu Y, Zhu SY, Li WX.