General Information

    • DRAMP ID

    • DRAMP03752

    • Peptide Name

    • Peptide BmKb1 (Non-disulfide-bridged peptide 4.2, NDBP-4.2; Arthropods, animals)

    • Source

    • Mesobuthus martensii (Manchurian scorpion)

    • Family

    • Not found

    • Gene

    • Kb1

    • Sequence

    • FLFSLIPSAISGLISAFK

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=16 µg/ml), Micrococcus luteus(MIC=81.5 µg/ml), Bacillus subtilis (MIC=48.8 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=18.1 µg/ml), Pseudomonas aeruginosa (MIC=90.8 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane (Forms a helical membrane channel in the prey)

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03752 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C94H147N19O23

    • Absent Amino Acids

    • CDEHMNQRTVWY

    • Common Amino Acids

    • S

    • Mass

    • 1911.31

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +1

    • Boman Index

    • 23.87

    • Hydrophobicity

    • 1.544

    • Aliphatic Index

    • 141.11

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP03752

DRAMP03752 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.

    • Tissue specificity

    • Expressed by the venom gland.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch.

    • Reference

    • Peptides. 2004 Feb;25(2):143-150.

    • Author

    • Zeng XC, Wang SX, Zhu Y, Zhu SY, Li WX.
  • ·Literature 2

    • Title

    • Genomic organization of four novel nondisulfide-bridged peptides from scorpion Mesobuthus martensii Karsch: gaining insight into evolutionary mechanism.

    • Reference

    • Peptides. 2005 Dec;26(12):2427-2433.

    • Author

    • Luo F, Zeng XC, Hahin R, Cao ZJ, Liu H, Li WX.