General Information

    • DRAMP ID

    • DRAMP03756

    • Peptide Name

    • Cytotoxic linear peptide (Non-disulfide bridged protein family 5, NDBP-5; Arthropods, animals)

    • Source

    • Pandinus cavimanus (Tanzanian red clawed scorpion)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLGGLWKAMSNLL

    • Sequence Length

    • 13

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03756 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03756.

Physicochemical Information

    • Formula

    • C69H108N16O16S

    • Absent Amino Acids

    • CDEHIPQRTVY

    • Common Amino Acids

    • L

    • Mass

    • 1449.77

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 15.44

    • Hydrophobicity

    • 0.908

    • Aliphatic Index

    • 127.69

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 458.33

    • Polar Residues

    • 4

DRAMP03756

Comments Information

    • Function

    • Amphipathic peptide that has antibacterial activities.

Literature Information

  • ·Literature 1

    • Title

    • Molecular diversity of the telson and venom components from Pandinus cavimanus (Scorpionidae Latreille 1802): transcriptome, venomics and function.

    • Reference

    • Proteomics. 2012 Jan;12(2):313-328.

    • Author

    • Diego-García E, Peigneur S, Clynen E, Marien T, Czech L, Schoofs L, Tytgat J.