General Information

    • DRAMP ID

    • DRAMP03776

    • Peptide Name

    • UyCT3 (Arthropods, animals)

    • Source

    • Urodacus yaschenkoi (Scorpion)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ILSAIWSGIKSLF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.23182832]Gram-positive bacterium: Staphylococcus aureus ATCC 25953 (MIC=10 µM);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 µM), Pseudomonas aeruginosa ATCC 9027 (MIC=6 µM).

    • Hemolytic Activity

      • [Ref.23182832]30% hemolytic activity at 12.5 μM, 90% hemolytic activity at 25 μM, 92% hemolytic activity at 50 μM, 90% hemolytic activity at 100 μM against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03776 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C70H111N15O17

    • Absent Amino Acids

    • CDEHMNPQRTVY

    • Common Amino Acids

    • IS

    • Mass

    • 1434.74

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +1

    • Boman Index

    • 16.91

    • Hydrophobicity

    • 1.392

    • Aliphatic Index

    • 157.69

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 458.33

    • Polar Residues

    • 4

DRAMP03776

Comments Information

    • Function

    • Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity.

    • Reference

    • Toxicon. 2013 Mar 1;63:44-54.

    • Author

    • Luna-Ramírez K, Quintero-Hernández V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD.