General Information

    • DRAMP ID

    • DRAMP03778

    • Peptide Name

    • Agrocybin (Fungus)

    • Source

    • Agrocybe cylindracea (Toadstool)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ANDPQCLYGNVAAKF

    • Sequence Length

    • 15

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Antiviral

    • Target Organism

    • Mycosphaerella arachidicola (IC50=125 µM), HIV-1 reverse transcriptase (IC50=60 µM), Pseudomonas fluorescens.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03778 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03778.

Physicochemical Information

    • Formula

    • C71H107N19O22S

    • Absent Amino Acids

    • EHIMRSTW

    • Common Amino Acids

    • A

    • Mass

    • 1610.8

    • PI

    • 5.87

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • 0

    • Boman Index

    • -13.64

    • Hydrophobicity

    • -0.167

    • Aliphatic Index

    • 65.33

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 106.43

    • Polar Residues

    • 5

DRAMP03778

Comments Information

    • Function

    • Has mitogenic activity towards murine splenocytes. Lacks antiproliferative activity towards HepG2 hepatoma cells.

Literature Information

  • ·Literature 1

    • Title

    • Agrocybin, an antifungal peptide from the edible mushroom Agrocybe cylindracea.

    • Reference

    • Peptides. 2005 Feb;26(2):191-196.

    • Author

    • Ngai PH, Zhao Z, Ng TB.