General Information

    • DRAMP ID

    • DRAMP03782

    • Peptide Name

    • Corticostatin-related peptide LCRP (alpha-defensin)

    • Source

    • Petromyzon marinus (Sea lamprey)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • CPCGRRRCCVRGLNVYCCF

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03782 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03782.

Physicochemical Information

    • Formula

    • C89H146N32O22S6

    • Absent Amino Acids

    • ADEHIKMQSTW

    • Common Amino Acids

    • C

    • Mass

    • 2208.7

    • PI

    • 8.98

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +4

    • Boman Index

    • -40.92

    • Hydrophobicity

    • 0.253

    • Aliphatic Index

    • 51.05

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 103.61

    • Polar Residues

    • 10

DRAMP03782

DRAMP03782 chydropathy plot

Comments Information

    • Function

    • May have microbicidal activities. May inhibit corticotropin (ACTH) stimulated steroidogenesis and the microbial actions of the corticostatins.

    • PTM

    • Problely contains three disulfide bonds 1-18; 3-9; 8-17.

Literature Information

  • ·Literature 1

    • Title

    • Isolation of a peptide structurally related to mammaliancorticostatins from the lamprey Petromyzon marinus.

    • Reference

    • Comp Biochem Physiol B Biochem Mol Biol. 1996 Jun;114(2):133-137.

    • Author

    • Conlon JM, Sower SA.