General Information

    • DRAMP ID

    • DRAMP03785

    • Peptide Name

    • Neuropeptide-like protein 29 (NLP-29; nematodes, animals)

    • Source

    • Caenorhabditis elegans

    • Family

    • Not found

    • Gene

    • nlp-29

    • Sequence

    • QWGYGGYGRGYGGYGGYGRGMYGGYGRGMYGGYGRGMYGGYGRGMYGGWGK

    • Sequence Length

    • 51

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: S. marcescens.
      • Fungi: D. coniospora.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03785 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03785.

Physicochemical Information

    • Formula

    • C243H324N70O65S4

    • Absent Amino Acids

    • ACDEFHILNPSTV

    • Common Amino Acids

    • G

    • Mass

    • 5393.92

    • PI

    • 9.79

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +6

    • Boman Index

    • -48.87

    • Hydrophobicity

    • -0.982

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 28880

    • Absorbance 280nm

    • 577.6

    • Polar Residues

    • 38

DRAMP03785

DRAMP03785 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptides that have antibacterial and antifungal activity.

    • Tissue specificity

    • Weakly or not expressed in absence of infection. Upon infection by D. coniospora, it is expressed in hypoderm. Also expressed in perivulval cells when D. coniospora spores adhere to this region.

    • Induction

    • Upon D. coniospora and S. marcescens infection.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species.

    • Reference

    • Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14000-14005.

    • Author

    • Nathoo AN, Moeller RA, Westlund BA, Hart AC.
  • ·Literature 2

    • Title

    • TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.

    • Reference

    • Nat Immunol. 2004 May;5(5):488-494.

    • Author

    • Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ.