General Information

    • DRAMP ID

    • DRAMP03788

    • Peptide Name

    • Neuropeptide-like protein 33 (NLP-33; nematodes, animals)

    • Source

    • Caenorhabditis elegans

    • Family

    • Not found

    • Gene

    • nlp-33

    • Sequence

    • QWGYGGPYGGYGGGYGGGPWGYGGGWRRRHWGGYGGGPWGGYGGGPWGGYY

    • Sequence Length

    • 51

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

      • Fungi: Drechmeria coniospora.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03788 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03788.

Physicochemical Information

    • Formula

    • C250H303N69O62

    • Absent Amino Acids

    • ACDEFIKLMNSTV

    • Common Amino Acids

    • G

    • Mass

    • 5266.58

    • PI

    • 9.46

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -16.86

    • Hydrophobicity

    • -1.069

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 46410

    • Absorbance 280nm

    • 928.2

    • Polar Residues

    • 36

DRAMP03788

DRAMP03788 chydropathy plot

Comments Information

    • Function

    • May have antifungic activity.

    • Tissue specificity

    • Expressed in hypoderm.

    • Induction

    • Strongly up-regulated upon D. coniospora infection.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Genome sequence of the nematode C. elegans: a platform for investigating biology.

    • Reference

    • Science. 1998 Dec 11;282(5396):2012-2018.

    • Author

    • C. elegans Sequencing Consortium.
  • ·Literature 2

    • Title

    • TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.

    • Reference

    • Nat Immunol. 2004 May;5(5):488-494.

    • Author

    • Couillault C, Pujol N, Reboul J, Sabatier L, Guichou JF, Kohara Y, Ewbank JJ.