General Information

    • DRAMP ID

    • DRAMP03800

    • Peptide Name

    • Neutrophil antibiotic peptide NP-5 (Microbicidal peptide NP-5; lagomorphs, mammals, animals)

    • Source

    • Oryctolagus cuniculus (Rabbit)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • VFCTCRGFLCGSGERASGSCTINGVRHTLCCRR

    • Sequence Length

    • 33

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03800 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03800.

Physicochemical Information

    • Formula

    • C143H237N51O43S6

    • Absent Amino Acids

    • DKMPQWY

    • Common Amino Acids

    • C

    • Mass

    • 3551.13

    • PI

    • 9.01

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +5

    • Boman Index

    • -67.63

    • Hydrophobicity

    • 0.112

    • Aliphatic Index

    • 56.06

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 11.72

    • Polar Residues

    • 18

DRAMP03800

DRAMP03800 chydropathy plot

Comments Information

    • Function

    • Microbicidal activity. PTM

Literature Information

  • ·Literature 1

    • Title

    • Differential expression of corticostatins/defensins: higher levels of CS-4 (NP-2) transcripts compared with CS-6 (NP-5) in rabbit lung.

    • Reference

    • Biochem Biophys Res Commun. 1993 Feb 15;190(3):1009-1016.

    • Author

    • Sadro LC, Tremblay A, Solomon S, Palfree RG.
  • ·Literature 2

    • Title

    • Solution structures of the rabbit neutrophil defensin NP-5.

    • Reference

    • J Mol Biol. 1988 Jun 5;201(3):625-636.

    • Author

    • Pardi A, Hare DR, Selsted ME, Morrison RD, Bassolino DA, Bach AC 2nd.