General Information

    • DRAMP ID

    • DRAMP03801

    • Peptide Name

    • Neutrophil antibiotic peptide NP-4 (Microbicidal peptide NP-4; lagomorphs, mammals, animals)

    • Source

    • Oryctolagus cuniculus (Rabbit)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • VSCTCRRFSCGFGERASGSCTVNGVRHTLCCRR

    • Sequence Length

    • 33

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03801 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03801.

Physicochemical Information

    • Formula

    • C143H238N54O44S6

    • Absent Amino Acids

    • DIKMPQWY

    • Common Amino Acids

    • CR

    • Mass

    • 3610.16

    • PI

    • 9.3

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +6

    • Boman Index

    • -92.69

    • Hydrophobicity

    • -0.161

    • Aliphatic Index

    • 41.21

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 11.72

    • Polar Residues

    • 18

DRAMP03801

DRAMP03801 chydropathy plot

Comments Information

    • Function

    • Microbicidal activity. PTM

Literature Information

  • ·Literature 1

    • Title

    • Cationic defensins arise from charge-neutralized propeptides: amechanism for avoiding leukocyte autocytotoxicity?

    • Reference

    • J Leukoc Biol. 1992 Jun;51(6):634-639.

    • Author

    • Michaelson D, Couto M, Rayner J.R, Ganz T.
  • ·Literature 2

    • Title

    • Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.

    • Reference

    • J Biol Chem. 1985 Apr 25;260(8):4579-4584.

    • Author

    • Selsted ME, Brown DM, DeLange RJ, Harwig SS, Lehrer RI.