General Information
-
DRAMP ID
- DRAMP03803
-
Peptide Name
- Corticostatin-2 (Antiadrenocorticotropin peptide II; Corticostatin II; lagomorphs, mammals, anima
-
Source
- Oryctolagus cuniculus (Rabbit)
-
Family
- Belongs to the alpha-defensin family
-
Gene
- Not found
-
Sequence
- GRCVCRKQLLCSYRERRIGDCKIRGVRFPFCCPR
-
Sequence Length
- 34
-
UniProt Entry
- P07468
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Unknown
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03803.
Physicochemical Information
-
Formula
- C172H289N61O42S6
Absent Amino Acids
- AHMNTW
Common Amino Acids
- R
Mass
- 4075.93
PI
- 9.99
Basic Residues
- 10
Acidic Residues
- 2
Hydrophobic Residues
- 8
Net Charge
- +8
-
Boman Index
- -110.85
Hydrophobicity
- -0.447
Aliphatic Index
- 62.94
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1865
Absorbance 280nm
- 56.52
Polar Residues
- 11
DRAMP03803
Comments Information
Function
- Microbicidal activity and inhibits corticotropin (ACTH) stimulated corticosterone production.
PTM
- Problely contains three disulfide bonds 3-32; 5-21; 11-31.
Literature Information
- ·Literature 1
-
Title
- Primary structures of six antimicrobial peptides of rabbit peritonealneutrophils.
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Pubmed ID
- 3988726
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Reference
- J Biol Chem. 1985 Apr 25;260(8):4579-4584.
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Author
- Selsted ME, Brown DM, DeLange RJ, Harwig SS, Lehrer RI.
- ·Literature 2
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Title
- Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides.
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Pubmed ID
- 1311240
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Reference
- Endocrinology. 1992 Mar;130(3):1413-1423.
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Author
- Zhu Q, Solomon S.