General Information

    • DRAMP ID

    • DRAMP03805

    • Peptide Name

    • Corticostatin-4 (Corticostatin IV; Macrophage antibiotic peptide MCP-2; lagomorphs, mammals, anim

    • Source

    • Oryctolagus cuniculus (Rabbit)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • VVCACRRALCLPLERRAGFCRIRGRIHPLCCRR

    • Sequence Length

    • 33

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Antiviral

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03805 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03805.

Physicochemical Information

    • Formula

    • C161H282N62O36S6

    • Absent Amino Acids

    • DKMNQSTWY

    • Common Amino Acids

    • R

    • Mass

    • 3854.76

    • PI

    • 11.12

    • Basic Residues

    • 10

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +9

    • Boman Index

    • -90.18

    • Hydrophobicity

    • 0.139

    • Aliphatic Index

    • 97.58

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 11.72

    • Polar Residues

    • 8

DRAMP03805

DRAMP03805 chydropathy plot

Comments Information

    • Function

    • This peptide has antibiotic, anti-fungi and antiviral activity. It also inhibits corticotropin (ACTH) stimulated corticosterone production.

    • PTM

    • Problely contains three disulfide bonds 3-31; 5-20; 10-30.

Literature Information

  • ·Literature 1

    • Title

    • Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of Rabbit lung macrophages.

    • Reference

    • J Biol Chem. 1983 Dec 10;258(23):14485-14489.

    • Author

    • Selsted ME, Brown DM, DeLange RJ, Lehrer RI.
  • ·Literature 2

    • Title

    • Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.

    • Reference

    • J Biol Chem. 1985 Apr 25;260(8):4579-4584.

    • Author

    • Selsted ME, Brown DM, DeLange RJ, Harwig SS, Lehrer RI.
  • ·Literature 3

    • Title

    • Isolation and mode of action of rabbit corticostatic (antiadrenocorticotrop

    • Reference

    • Endocrinology. 1992 Mar;130(3):1413-1423.

    • Author

    • Zhu Q, Solomon S.