General Information

    • DRAMP ID

    • DRAMP03806

    • Peptide Name

    • Corticostatin-6 (Corticostatin VI; Neutrophil antibiotic peptide NP-6; lagomorphs, mammals, anima

    • Source

    • Oryctolagus cuniculus (Rabbit)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Not found

    • Sequence

    • GICACRRRFCLNFEQFSGYCRVNGARYVRCCSRR

    • Sequence Length

    • 34

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03806 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03806.

Physicochemical Information

    • Formula

    • C169H269N61O44S6

    • Absent Amino Acids

    • DHKMPTW

    • Common Amino Acids

    • R

    • Mass

    • 4051.74

    • PI

    • 9.8

    • Basic Residues

    • 8

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +7

    • Boman Index

    • -111.09

    • Hydrophobicity

    • -0.344

    • Aliphatic Index

    • 45.88

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 3355

    • Absorbance 280nm

    • 101.67

    • Polar Residues

    • 15

DRAMP03806

DRAMP03806 chydropathy plot

Comments Information

    • Function

    • Microbicidal activity and inhibits corticotropin (ACTH) stimulated corticosterone production.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of new anti-adrenocorticotropin Rabbit neutrophil peptides (defensins).

    • Reference

    • Eur J Biochem. 1993 Sep 1;216(2):653-659.

    • Author

    • Fuse N, Hayashi Y, Fukata J, Tominaga T, Ebisui O, Satoh Y, Isohara T, Uno I, Imura H.