General Information
-
DRAMP ID
- DRAMP03810
-
Peptide Name
- Pardaxin P-2 (Pardaxin Pa2)
-
Source
- Pardachirus pavoninus (Peacock sole) (Achirus pavoninus)
-
Family
- Belongs to the pardaxin family
-
Gene
- Not found
-
Sequence
- GFFALIPKIISSPIFKTLLSAVGSALSSSGGQE
-
Sequence Length
- 33
-
UniProt Entry
- P23067
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Cytotoxic
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Cell membrane
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
-
Structure Description
- Pardaxin P-2 adopts a novel amphiphilic helix (7-11)-bend (12-13)-helix (14-26) motif with Pro-13 forming the focal point of the turn or bend between the two helices.(Ref.2)
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03810.
Physicochemical Information
-
Formula
- C154H248N36O45
Absent Amino Acids
- CDHMNRWY
Common Amino Acids
- S
Mass
- 3323.88
PI
- 8.59
Basic Residues
- 2
Acidic Residues
- 1
Hydrophobic Residues
- 15
Net Charge
- +1
-
Boman Index
- 11.71
Hydrophobicity
- 0.767
Aliphatic Index
- 112.42
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 12
DRAMP03810
Comments Information
Function
- Exhibits unusual shark repellent and surfactant properties. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Subunit structure
- In aqueous solution exists as a tetramer.
Domain
- Consists of a C-terminal hydrophilic region and a predominantly hydrophobic remainder.
Literature Information
- ·Literature 1
-
Title
- Melittin-like peptides from the shark-repelling defense secretion of the sole Pardachirus pavoninus.
-
Pubmed ID
- 17737623
-
Reference
- Science. 1986 Jul 18;233(4761):341-343.
-
Author
- Thompson SA, Tachibana K, Nakanishi K, Kubota I.
- ·Literature 2
-
Title
- Solution structure of pardaxin P-2.
-
Pubmed ID
- 1868074
-
Reference
- Biochemistry. 1991 Aug 13;30(32):8009-8017.
-
Author
- Zagorski MG, Norman DG, Barrow CJ, Iwashita T, Tachibana K, Patel DJ.