General Information

    • DRAMP ID

    • DRAMP03819

    • Peptide Name

    • Cyclic hexapeptide CYC-(RRWWRF)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RRWWRF

    • Sequence Length

    • 6

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.16075425] Gram-negative bacterium: Escherichia coli(MIC=6.3 μM);
      • Gram-positive bacterium: Bacillus subtilis(MIC=3.1 μM)

    • Hemolytic Activity

      • [Ref.16075425] It has 24% hemolysis at 100 μM against erythrocytes.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • No specific N-terminal

    • C-terminal Modification

    • No specific C-terminal

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Non helix or strand structure (Turn)

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03819 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP03819.

Physicochemical Information

    • Formula

    • C49H67N17O7

    • Absent Amino Acids

    • ACDEGHIKLMNPQSTVY

    • Common Amino Acids

    • R

    • Mass

    • 1006.18

    • PI

    • 12.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +3

    • Boman Index

    • -37.12

    • Hydrophobicity

    • -2.083

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 2200

    • Polar Residues

    • 0

DRAMP03819

Comments Information

    • Function

    • Antibacterial activity against Escherichia coli and Bacillus subtilis. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles.

    • Reference

    • Chembiochem. 2005 Sep;6(9):1654-1662.

    • Author

    • Appelt C, Wessolowski A, S?derh??ll JA, Dathe M, Schmieder P.
  • ·Literature 2

    • Title

    • The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries.

    • Reference

    • J Appl Bacteriol. 1995 Jan;78(1):39-46.

    • Author

    • Blondelle SE, Takahashi E, Dinh KT, Houghten RA.