• • DRAMP ID

  • DRAMP03821

• • Peptide Name

  • Cyclic hexapeptide KKWWKF

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • KKWWKF

• • Sequence Length

  • 6

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.16075425] Gram-negative bacterium: Escherichia coli(MIC=25 μM);
    • Gram-positive bacterium: Bacillus subtilis(MIC=25 μM)

• • Hemolytic Activity

  • • [Ref.16075425] It has 10% hemolysis at 100 μM against erythrocytes.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • No specific N-terminal

• • C-terminal Modification

  • No specific C-terminal

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Non helix or strand structure (Turn)

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 1SKK

• Predicted Structure

• There is no predicted structure for DRAMP03821.

DRAMP03821

• • Function

  • Antibacterial activity against Escherichia coli and Bacillus subtilis. Has hemolytic activity.

• ·Literature 1

• • Title

  • Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles.

• • Pubmed ID

  • 16075425

• • Reference

  • Chembiochem. 2005 Sep;6(9):1654-1662.

• • Author

  • Appelt C, Wessolowski A, S?derh??ll JA, Dathe M, Schmieder P.