General Information

    • DRAMP ID

    • DRAMP03822

    • Peptide Name

    • Cyclic hexapeptide RR(NAL)(NAL)RF

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RRAARF

    • Sequence Length

    • 6

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • No secondary structure

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03822 helical wheel diagram

    • PDB ID

    • 1SKL resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP03822.

Physicochemical Information

    • Formula

    • C33H57N15O7

    • Absent Amino Acids

    • CDEGHIKLMNPQSTVWY

    • Common Amino Acids

    • R

    • Mass

    • 775.91

    • PI

    • 12.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +3

    • Boman Index

    • -38.16

    • Hydrophobicity

    • -1.183

    • Aliphatic Index

    • 33.33

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP03822

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles.

    • Reference

    • Chembiochem. 2005 Sep;6(9):1654-1662.

    • Author

    • Appelt C, Wessolowski A, SöderhÃäll JA, Dathe M, Schmieder P.