General Information

    • DRAMP ID

    • DRAMP03824

    • Peptide Name

    • CNBr-cleaved lactoferricin Subfragment 1

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FKCRRWQWR

    • Sequence Length

    • 9

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli L361 (MIC=10 µM), Pseudomonas fluorescens (MIC=50 µM), Salmonella Salford (MIC>50 µM), Escherichia coli O:9 (MIC=15 µM);
      • Gram-positive bacteria: Bacillus cereus (MIC=20 µM), Listeria monocytogenes (MIC=10 µM), Staphylococcus aureus (MIC>50 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Linked with a homoserine lactone

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03824 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03824.

Physicochemical Information

    • Formula

    • C63H92N22O11S

    • Absent Amino Acids

    • ADEGHILMNPSTVY

    • Common Amino Acids

    • R

    • Mass

    • 1365.62

    • PI

    • 11.71

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +4

    • Boman Index

    • -46.93

    • Hydrophobicity

    • -1.933

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 1375

    • Polar Residues

    • 1

DRAMP03824

Comments Information

    • Function

    • The antibacterial activity of this subfragment 1 is not as potent as that of intact lactoferricin, having an MIC of 10 to 50 µM for most of the bacteria tested.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial activity in bovine lactoferrin-derived peptides.

    • Reference

    • Antimicrob Agents Chemother. 1997 Jan;41(1):54-59.

    • Author

    • Hoek KS, Milne JM, Grieve PA, Dionysius DA, Smith R.