General Information

    • DRAMP ID

    • DRAMP03829

    • Peptide Name

    • GLK-19

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLKKLLGKLLKKLGKLLLK

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Anticancer

    • Target Organism

      • Gram-negative bacterium: Escherichia coli K12 (MIC=10 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03829 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C102H194N26O20

    • Absent Amino Acids

    • ACDEFHIMNPQRSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 2104.82

    • PI

    • 10.78

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +7

    • Boman Index

    • 8.25

    • Hydrophobicity

    • 0.3

    • Aliphatic Index

    • 184.74

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP03829

DRAMP03829 chydropathy plot

Comments Information

    • Function

    • GLK-19 showed a higher activity against Escherichia coli than human LL-37.

Literature Information

  • ·Literature 1

    • Title

    • APD2: the updated antimicrobial peptide database and its application in peptide design.

    • Reference

    • Nucleic Acids Res. 2009 Jan;37(Database issue):D933-937.

    • Author

    • Wang G, Li X, Wang Z.