General Information
-
DRAMP ID
- DRAMP03839
-
Peptide Name
- ETD131 (Mutant of ARD1; Heliomicin analogs)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- DKLIGSCVWGAVNYTSNCNAECKRRGYKGGHCGSFANVNCWCQT
-
Sequence Length
- 44
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- Fungi: Candida albicans IHEM 8060 (MIC50=3.125 µg/ml), Aspergillus fumigatus GASP4707 (MIC50=3.125 µg/ml), Cryptococcus neoformans A (MIC50=12.5 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03839.
Physicochemical Information
-
Formula
- C202H307N63O62S6
Absent Amino Acids
- MP
Common Amino Acids
- CG
Mass
- 4802.4
PI
- 8.65
Basic Residues
- 6
Acidic Residues
- 2
Hydrophobic Residues
- 11
Net Charge
- +4
-
Boman Index
- -72.69
Hydrophobicity
- -0.418
Aliphatic Index
- 44.32
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 14355
Absorbance 280nm
- 333.84
Polar Residues
- 24
DRAMP03839
Comments Information
Function
- Possess antifungal activity.
Literature Information
- ·Literature 1
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Title
- Lead optimization of antifungal peptides with 3D NMR structures analysis.
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Pubmed ID
- 14978308
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Reference
- Protein Sci. 2004 Mar;13(3):703-713.
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Author
- Landon C, Barbault F, Legrain M, Menin L, Guenneugues M, Schott V, Vovelle F, Dimarcq JL.