General Information

    • DRAMP ID

    • DRAMP03851

    • Peptide Name

    • Cyclic L27-11 (protegrin-1-mimetic)

    • Source

    • Synthetic construct (peptide library screen)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • TWLKKRRWKKAKPP

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Pseudomonas aeruginosa (Remarkably).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Gram-negative bacterial outer membrane protein LptD

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03851 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03851.

Physicochemical Information

    • Formula

    • C87H143N27O16

    • Absent Amino Acids

    • CDEFGHIMNQSVY

    • Common Amino Acids

    • K

    • Mass

    • 1823.26

    • PI

    • 12.04

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +7

    • Boman Index

    • -48.77

    • Hydrophobicity

    • -2.043

    • Aliphatic Index

    • 35

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 846.15

    • Polar Residues

    • 1

DRAMP03851

Comments Information

    • Function

    • This circular peptide is designed as a mimic of PG-1. The peptidomimetics had a non-membrane-lytic mechanism of action and identified a homolog of the beta-barrel protein LptD (Imp/OstA), which functions in outer-membrane biogenesis, as a cellular target. Animal model (mouse)

Literature Information

  • ·Literature 1

    • Title

    • Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa.

    • Reference

    • Science. 2010 Feb 19;327(5968):1010-1013.

    • Author

    • Srinivas N, Jetter P, Ueberbacher BJ, Werneburg M, Zerbe K, Steinmann J, Van der Meijden B, Bernardini F, Lederer A, Dias RL, Misson PE, Henze H, Zumbrunn J, Gombert FO, Obrecht D, Hunziker P, Schauer S, Ziegler U, KÃäch A, Eberl L, Riedel K, DeMarco SJ, Robinson JA.