• • DRAMP ID

  • DRAMP03868

• • Peptide Name

  • Bac8c (Bac2A variant)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • RIWVIWRR

• • Sequence Length

  • 8

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • Gram-negative bacteria: Pseudomonas aeruginosa (MIC=8 µg/ml), Escherichia coli (MIC=2 µg/ml), Salmonella typhimurium (MIC=8 µg/ml);
    • Gram-positive bacteria: Staphylococcus aureus (MIC=2 µg/ml), Staphylococcus epidermidis (MIC=2 µg/ml), Enterococcus faecalis (MIC=2 µg/ml).
    • Yeast: Candida albicans (MIC=8 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP03868.

DRAMP03868

• • Function

  • 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans.

• • Chemical modification

  • C-terminal amidation.

• ·Literature 1

• • Title

  • High-throughput generation of small antibacterial peptides with improved activity.

• • Pubmed ID

  • 16041366

• • Reference

  • Nat Biotechnol. 2005 Aug;23(8):1008-1012.

• • Author

  • Hilpert K, Volkmer-Engert R, Walter T, Hancock RE.