• DRAMP ID

    • DRAMP03869
    • Peptide Name

    • Bac8d (Bac2A variant)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RRWVIWRR
    • Sequence Length

    • 8
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacteria: Pseudomonas aeruginosa (MIC=250 µg/ml), Escherichia coli (MIC=16 µg/ml), Salmonella typhimurium (MIC=31 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=16 µg/ml), Staphylococcus epidermidis (MIC=8 µg/ml), Enterococcus faecalis (MIC=32 µg/ml).
      • Yeast: Candida albicans (MIC=63 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03869 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03869.
    • Formula

    • C57H90N22O9
    • Absent Amino Acids

    • ACDEFGHKLMNPQSTY
    • Common Amino Acids

    • R
    • Mass

    • 1227.48
    • PI

    • 12.48
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +4
    • Boman Index

    • -46.06
    • Hydrophobicity

    • -1.388
    • Aliphatic Index

    • 85
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 11000
    • Absorbance 280nm

    • 1571.43
    • Polar Residues

    • 0

DRAMP03869

    • Function

    • 8-mer substituted peptide that showes broad spectrum activity against bacteria and the yeast C. albicans.
    • Chemical modification

    • C-terminal amidation.
  • ·Literature 1
    • Title

    • High-throughput generation of small antibacterial peptides with improved activity.
    • Reference

    • Nat Biotechnol. 2005 Aug;23(8):1008-1012.
    • Author

    • Hilpert K, Volkmer-Engert R, Walter T, Hancock RE.