General Information
-
DRAMP ID
- DRAMP03871
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Peptide Name
- cLf 20-29 (fragment of caprine lalctoferricin, residues 20-29)
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Source
- Synthetic construct
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Family
- Not found
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Gene
- Not found
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Sequence
- YQWQRRMRKL
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Sequence Length
- 10
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
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- Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=308 µM), Escherichia coli (wild strain) (MIC>300 µM);
- Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=308 µM), Enterococcus faecalis ATCC 29212 (MIC>300 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP03871_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C65H105N23O14S
Absent Amino Acids
- ACDEFGHINPSTV
Common Amino Acids
- R
Mass
- 1464.75
PI
- 11.72
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 2
Net Charge
- +4
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Boman Index
- -51.93
Hydrophobicity
- -2.09
Aliphatic Index
- 39
Half Life
-
- Mammalian:2.8 hour
- Yeast:10 min
- E.coli:2 min
Extinction Coefficient Cystines
- 6990
Absorbance 280nm
- 776.67
Polar Residues
- 1
DRAMP03871
Comments Information
Function
- Shows antibacterial activity against both Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
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Title
- Antibacterial activity of short hydrophobic and basic-rich peptides.
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Pubmed ID
- 13677384
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Reference
- Am J Vet Res. 2003 Sep;64(9):1088-1092.
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Author
- Chen PW, Shyu CL, Mao FC.