General Information
-
DRAMP ID
- DRAMP03900
-
Peptide Name
- LFM A1,9 W8 (LFM W8 derivative with residues substitution)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
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Sequence
- AKCLRWQWAMRKVGG
-
Sequence Length
- 15
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- Gram-negative bacterium: Escherichia coli (MIC=134 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP03900_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C80H128N26O17S2
Absent Amino Acids
- DEFHINPSTY
Common Amino Acids
- AGKRW
Mass
- 1790.18
PI
- 11.01
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +4
-
Boman Index
- -23.73
Hydrophobicity
- -0.46
Aliphatic Index
- 58.67
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 785.71
Polar Residues
- 3
DRAMP03900
Comments Information
Function
- Has antibacterial activity against the Gram-negative bacteria E. coli.
Literature Information
- ·Literature 1
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Title
- Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
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Pubmed ID
- 11168896
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Reference
- J Pept Res. 2001 Feb;57(2):127-139.
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Author
- Strøm MB, Rekdal O, Stensen W, Svendsen JS.