General Information

    • DRAMP ID

    • DRAMP03906

    • Peptide Name

    • LFM A1 W8 Y13 (LFM W8 derivative with residues substitution)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AKCLRWQWEMRKYGG

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=151 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03906 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C86H130N26O20S2

    • Absent Amino Acids

    • DFHINPSTV

    • Common Amino Acids

    • GKRW

    • Mass

    • 1912.26

    • PI

    • 9.78

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +3

    • Boman Index

    • -36.53

    • Hydrophobicity

    • -1.18

    • Aliphatic Index

    • 32.67

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 12490

    • Absorbance 280nm

    • 892.14

    • Polar Residues

    • 4

DRAMP03906

Comments Information

    • Function

    • Has antibacterial activity against the Gram-negative bacteria E. coli.

Literature Information

  • ·Literature 1

    • Title

    • Increased antibacterial activity of 15-residue murine lactoferricin derivatives.

    • Reference

    • J Pept Res. 2001 Feb;57(2):127-139.

    • Author

    • Strøm MB, Rekdal O, Stensen W, Svendsen JS.