General Information

    • DRAMP ID

    • DRAMP03935

    • Peptide Name

    • V16M (truncated isoform of thanatin, residue 6-21)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VPIIYCNRRTGKCQRM

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Aerococcus viridans (MIC=1.2-2.5 µM), Micrococcus luteus (MIC=2.5-5 µM), Bacillus megaterium (MIC=5-10 µM), Bacillus subtilis (MIC=20-40 µM), Pediococcus acidilactici (MIC=20-40 µM);
      • Gram-negative bacteria: Escherichia coli D22 (MIC=0.6-1.2 µM), Escherichia coli D31 (MIC=0.6-1.2 µM), Klebsiella pneumoniae (MIC=2.5-5 µM), Enterobacter cloacae (MIC=5-10 µM), E. carotovora (MIC=20-40 µM).
      • Fungi: Neurospora crassa (MIC=10-20 µM), Botrytis cinerea (MIC=10-20 µM), Nectria haematococca (MIC=5-10 µM), Trichoderma viride (MIC=20-40 µM), Alternaria brassicicola (MIC=5-10 µM), Fusarium culmorum (MIC=10-20 µM), A. pisi (MIC=20-40 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03935 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03935.

Physicochemical Information

    • Formula

    • C81H140N28O21S3

    • Absent Amino Acids

    • ADEFHLSW

    • Common Amino Acids

    • R

    • Mass

    • 1938.36

    • PI

    • 10.1

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +4

    • Boman Index

    • -45.47

    • Hydrophobicity

    • -0.519

    • Aliphatic Index

    • 66.88

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 107.67

    • Polar Residues

    • 6

DRAMP03935

Comments Information

    • Function

    • Has antibacterial and antifungal activity.

Literature Information

  • ·Literature 1

    • Title

    • Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.

    • Reference

    • Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.

    • Author

    • Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA.