• • DRAMP ID

  • DRAMP03936

• • Peptide Name

  • K18M (truncated isoform of thanatin, residue 4-21)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • KPVPIIYCNRRTGKCQRM

• • Sequence Length

  • 18

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • Gram-positive bacteria: Aerococcus viridans (MIC=0.6-1.2 µM), Micrococcus luteus (MIC=1.2-2.5 µM), Bacillus megaterium (MIC=2.5-5 µM), Bacillus subtilis (MIC=20-40 µM), Pediococcus acidilactici (MIC=20-40 µM);
    • Gram-negative bacteria: Escherichia coli D22 (MIC=0.3-0.6 µM), Escherichia coli D31 (MIC=0.3-0.6 µM), Escherichia coli 1106 (MIC=0.6-1.2 µM), Salmonella typhimuriumn (MIC=1.2-2.5 µM), Klebsiella pneumoniae (MIC=1.2-2.5 µM), Enterobacter cloacae (MIC1.2-2.5 µM), E. carotovora (MIC=20-40 µM), Pseudomonas aeruginosa (MIC=20-40 µM).
    • Fungi: Neurospora crassa (MIC=2.5-5 µM), Botrytis cinerea (MIC=1.2-2.5 µM), Nectria haematococca (MIC=5-10 µM), Trichoderma viride (MIC=2.5-5 µM), Alternaria brassicicola (MIC=2.5-5 µM), Fusarium culmorum (MIC=5-10 µM), A. pisi (MIC=10-20 µM), Fusarium oxysporumn (MIC=20-40 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP03936.

DRAMP03936

• • Function

  • Has antibacterial and antifungal activity.

• ·Literature 1

• • Title

  • Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.

• • Pubmed ID

  • 8577744

• • Reference

  • Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.

• • Author

  • Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA.