• DRAMP ID

    • DRAMP03938
    • Peptide Name

    • G19Q (truncated isoform of thanatin, residue 1-19)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GSKKPVPIIYCNRRTGKCQ
    • Sequence Length

    • 19
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
    • Target Organism

      • Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 µM), Micrococcus luteus (MIC=5-10 µM), Bacillus megaterium (MIC=5-10 µM), Pediococcus acidilactici (MIC=20-40 µM).
      • Fungi: Neurospora crassa (MIC=10-20 µM), Botrytis cinerea (MIC=5-10 µM), Nectria haematococca (MIC=5-10 µM), Trichoderma viride (MIC=10-20 µM), Alternaria brassicicola (MIC=5-10 µM), Fusarium culmorum (MIC=10-20 µM), A. pisi (MIC=20-40 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03938 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03938.
    • Formula

    • C92H158N30O25S2
    • Absent Amino Acids

    • ADEFHLMW
    • Common Amino Acids

    • K
    • Mass

    • 2148.57
    • PI

    • 10.06
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 3
    • Net Charge

    • +5
    • Boman Index

    • -46.46
    • Hydrophobicity

    • -0.858
    • Aliphatic Index

    • 56.32
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1615
    • Absorbance 280nm

    • 89.72
    • Polar Residues

    • 8

DRAMP03938

DRAMP03938 chydropathy plot
    • Function

    • Has antibacterial and antifungal activity.
  • ·Literature 1
    • Title

    • Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.
    • Reference

    • Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-1225.
    • Author

    • Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA.