General Information

    • DRAMP ID

    • DRAMP03942

    • Peptide Name

    • Peptide 2 (Trp- and Arg-rich; derivative of Tritrpticin)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RRRFPWVCWPFLRRR

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis;
      • Gram-positive bacteria: Staphylococcus epidermidis, Streptococcus group D.
      • Fungi: Aspergillus fumigatus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03942 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03942.

Physicochemical Information

    • Formula

    • C100H151N35O16S

    • Absent Amino Acids

    • ADEGHIKMNQSTY

    • Common Amino Acids

    • R

    • Mass

    • 2131.58

    • PI

    • 12.3

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +6

    • Boman Index

    • -68.66

    • Hydrophobicity

    • -1.06

    • Aliphatic Index

    • 45.33

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 785.71

    • Polar Residues

    • 1

DRAMP03942

Comments Information

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides.

    • Reference

    • FEBS Lett. 1996 Jul 15;390(1):95-98.

    • Author

    • Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K.