General Information

    • DRAMP ID

    • DRAMP03947

    • Peptide Name

    • Del 1-2 (Ranalexin analog)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GGLIKIVPAMICAVTKKC

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=256 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC>256 µg/ml), Pseudomonas aeruginosa (MIC>256 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03947 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03947.

Physicochemical Information

    • Formula

    • C82H149N21O20S3

    • Absent Amino Acids

    • DEFHNQRSWY

    • Common Amino Acids

    • IK

    • Mass

    • 1845.39

    • PI

    • 9.39

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +3

    • Boman Index

    • 18.95

    • Hydrophobicity

    • 1.189

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 7.35

    • Polar Residues

    • 5

DRAMP03947

DRAMP03947 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.

    • Reference

    • J Biol Chem. 1994 Apr 8;269(14):10849-10855.

    • Author

    • Clark DP, Durell S, Maloy WL, Zasloff M.