General Information

    • DRAMP ID

    • DRAMP03948

    • Peptide Name

    • Del 1 (Ranalexin analog)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LGGLIKIVPAMICAVTKKC

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC=256 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=256 µg/ml), Pseudomonas aeruginosa (MIC>256 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03948 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03948.

Physicochemical Information

    • Formula

    • C88H160N22O21S3

    • Absent Amino Acids

    • DEFHNQRSWY

    • Common Amino Acids

    • IK

    • Mass

    • 1958.55

    • PI

    • 9.39

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • 23.87

    • Hydrophobicity

    • 1.326

    • Aliphatic Index

    • 143.68

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.94

    • Polar Residues

    • 5

DRAMP03948

DRAMP03948 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.

    • Reference

    • J Biol Chem. 1994 Apr 8;269(14):10849-10855.

    • Author

    • Clark DP, Durell S, Maloy WL, Zasloff M.