General Information
-
DRAMP ID
- DRAMP03963
-
Peptide Name
- Cecropin A(1-8)-Magainin 2(1-12)hybrid peptide analogue (P1)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- KWKLFKKIKFLHSAKKF
-
Sequence Length
- 17
-
UniProt Entry
- P01507
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix (1 helices; 9 residues)
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- 1F0F resolved by NMR.
- 1F0F-> 
-
Predicted Structure
- There is no predicted structure for DRAMP03963.
Physicochemical Information
-
Formula
- C110H173N27O19
Absent Amino Acids
- CDEGMNPQRTVY
Common Amino Acids
- K
Mass
- 2177.75
PI
- 10.78
Basic Residues
- 8
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +8
-
Boman Index
- -19.07
Hydrophobicity
- -0.582
Aliphatic Index
- 74.71
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 343.75
Polar Residues
- 1
DRAMP03963
Comments Information
P1 has significantly decreased lytic activities against bacterial and tumor cells and PC/PS vesicles (3
- 1, w/w), and reduced pore-forming activity on lipid bilayers.
Literature Information
- ·Literature 1
-
Title
- Role of the hinge region and the tryptophan residue in the synthetic antimicrobial peptides, cecropin A(1-8)-magainin 2(1-12) and its analogues, on their antibiotic activities and structures.
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Pubmed ID
- 11009597
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Reference
- Biochemistry. 2000 Oct 3;39(39):11855-11864.
-
Author
- Oh D, Shin SY, Lee S, Kang JH, Kim SD, Ryu PD, Hahm KS, Kim Y.